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Article

Improving the clinical performance of blood-based DNA methylation biomarkers utilizing locus-specific epigenetic heterogeneity

2019-03-18

Abstract excerpt

<h4>Background</h4> Variation in intercellular methylation patterns can complicate the use of methylation biomarkers for clinical diagnostic applications such as blood-based cancer testing. Here, we describe development and validation of a methylation density binary classification method called EpiClass (available for download at https://github.com/Elnitskilab/EpiClass ), that can be used to predict and optimize...

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Literature Corpus work
c5d012ee-537e-5881-a366-3ca15166c7f8
DOI
10.1101/579839
Open publication

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Improving the clinical performance of blood-based DNA methylation biomarkers utilizing locus-specific epigenetic heterogeneityDOI 10.1101/579839
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