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Article

Thousands of CpGs Show DNA Methylation Differences in ACPA-Positive Individuals.

Genes - 29 Aug 2021

Zeng Yixiao, Zhao Kaiqiong, Oros Klein Kathleen, Shao Xiaojian, Fritzler Marvin J, Hudson Marie, Colmegna Inés, Pastinen Tomi, Bernatsky Sasha, Greenwood Celia M T

Abstract excerpt

High levels of anti-citrullinated protein antibodies (ACPA) are often observed prior to a diagnosis of rheumatoid arthritis (RA). We undertook a replication study to confirm CpG sites showing evidence of differential methylation in subjects positive vs. negative for ACPA, in a new subset of 112 individuals sampled from the population cohort and biobank CARTaGENE in Quebec, Canada. Targeted custom capture...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34573331
DOI: 10.3390/genes12091349
PMCID: PMC8472734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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