Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencing

31 Jul 2019

Abstract excerpt

OBJECTIVE: To compare DNA methylation in subjects positive vs negative for anti-citrullinated protein antibodies (ACPA), a key serological marker of rheumatoid arthritis (RA) risk. METHODS: With banked serum from a random subset (N = 3600) of a large general population cohort, we identified ACPA-positive samples and compared them to age- and sex-matched ACPA-negative controls. We used a custom-designed methylome...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune and Inflammatory Disorders Research
Share to Rheumatoid Arthritis Research and Therapies
Share to Spondyloarthritis Studies and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31366403
DOI: 10.1186/s13148-019-0699-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rheumatoid arthritis-relevant DNA methylation changes identified in ACPA-positive asymptomatic individuals using methylome capture sequencingPMID 31366403Read ↗

Thousands of CpGs Show DNA Methylation Differences in ACPA-Positive Individuals.Semantic proximity Read ↗

Epigenetic trajectory predicts development of clinical rheumatoid arthritis in anti-citrullinated protein antibody positive individuals: Targeting Immune Responses for Prevention of Rheumatoid Arthritis (TIP-RA)Semantic proximity Read ↗

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis.Semantic proximity Read ↗

DNA Methylation as a Future Therapeutic and Diagnostic Target in Rheumatoid ArthritisSemantic proximity Read ↗

Differential DNA methylation patterns in whole blood from ACPA-positive patients with DMARD-naïve rheumatoid arthritis at clinical disease onsetSemantic proximity Read ↗

Epigenome-wide association study of rheumatoid arthritis identifies differentially methylated loci in B cellsSemantic proximity Read ↗

Deep immunophenotyping reveals circulating activated lymphocytes in individuals at risk for rheumatoid arthritisSemantic proximity Read ↗

Next-Generation Sequencing Profiles of the Methylome and Transcriptome in Peripheral Blood Mononuclear Cells of Rheumatoid ArthritisSemantic proximity Read ↗

Differentially Methylated DNA Regions in Monozygotic Twin Pairs Discordant for Rheumatoid Arthritis: An Epigenome-Wide StudySemantic proximity Read ↗

Clinical value of DNA methylation markers in autoimmune rheumatic diseases.Semantic proximity Read ↗

Blood-based epigenetic biomarkers in rheumatoid arthritis: current knowledge and future perspectives.Semantic proximity Read ↗

Identifying AIM2 Circulating Methylation Levels as a Novel Diagnostic Biomarker for Rheumatoid Arthritis Using Targeted DNA Methylation SequencingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.