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Identification of Specific Joint-Inflammatogenic Cell-Free DNA Molecules From Synovial Fluids of Patients With Rheumatoid Arthritis

28 Apr 2020

Abstract excerpt

Elevated cell-free DNA (cfDNA) levels in the plasma and synovial fluid of rheumatoid arthritis (RA) patients are proposed to be pathologically relevant. However, direct evidence to support this perception is lacking, and molecular feature of the cfDNA molecules with assumed pathological function is not well characterized. Here we confirmed remarkably increased levels of total synovial fluid and plasma cfDNAs in a...

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PMID: 32411129
DOI: 10.3389/fimmu.2020.00662

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