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A Distinguishable Peripheral Blood and Conjunctival Transcriptome and Gut Microbiome in Sjögren's Disease: A Pilot Study

2 May 2025

Abstract excerpt

OBJECTIVE: To create a comprehensive multi-tissue molecular atlas of Sjögren's disease by using unbiased RNA sequencing to identify differentially expressed genes (DEGs) in peripheral blood and conjunctival transcriptomes, and to characterize the ocular surface and gut microbiome profiles in participants classified as Sjögren's versus non-Sjögren's disease. METHODS: This exploratory study used high-throughput RNA...

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Ocular Surface and Contact Lens
Oral microbiology and periodontitis research
Salivary Gland Disorders and Functions

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40314468
DOI: 10.1097/icl.0000000000001186

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