Article
Distinct interferon signatures and cytokine patterns define additional systemic autoinflammatory diseases.
The Journal of clinical investigation - 1 Apr 2020
de Jesus Adriana A, Hou Yangfeng, Brooks Stephen, Malle Louise, Biancotto Angelique, Huang Yan, Calvo Katherine R, Marrero Bernadette, Moir Susan, Oler Andrew J, Deng Zuoming, Montealegre Sanchez Gina A, Ahmed Amina, Allenspach Eric, Arabshahi Bita, Behrens Edward, Benseler Susanne, Bezrodnik Liliana, Bout-Tabaku Sharon, Brescia AnneMarie C, Brown Diane, Burnham Jon M, Caldirola Maria Soledad, Carrasco Ruy, Chan Alice Y, Cimaz Rolando, Dancey Paul, Dare Jason, DeGuzman Marietta, Dimitriades Victoria, Ferguson Ian, Ferguson Polly, Finn Laura, Gattorno Marco, Grom Alexei A, Hanson Eric P, Hashkes Philip J, Hedrich Christian M, Herzog Ronit, Horneff Gerd, Jerath Rita, Kessler Elizabeth, Kim Hanna, Kingsbury Daniel J, Laxer Ronald M, Lee Pui Y, Lee-Kirsch Min Ae, Lewandowski Laura, Li Suzanne, Lilleby Vibke, Mammadova Vafa, Moorthy Lakshmi N, Nasrullayeva Gulnara, O'Neil Kathleen M, Onel Karen, Ozen Seza, Pan Nancy, Pillet Pascal, Piotto Daniela Gp, Punaro Marilynn G, Reiff Andreas, Reinhardt Adam, Rider Lisa G, Rivas-Chacon Rafael, Ronis Tova, Rösen-Wolff Angela, Roth Johannes, Ruth Natasha Mckerran, Rygg Marite, Schmeling Heinrike, Schulert Grant, Scott Christiaan, Seminario Gisella, Shulman Andrew, Sivaraman Vidya, Son Mary Beth, Stepanovskiy Yuriy, Stringer Elizabeth, Taber Sara, Terreri Maria Teresa, Tifft Cynthia, Torgerson Troy, Tosi Laura, Van Royen-Kerkhof Annet, Wampler Muskardin Theresa, Canna Scott W, Goldbach-Mansky Raphaela
Abstract excerpt
BACKGROUNDUndifferentiated systemic autoinflammatory diseases (USAIDs) present diagnostic and therapeutic challenges. Chronic interferon (IFN) signaling and cytokine dysregulation may identify diseases with available targeted treatments.METHODSSixty-six consecutively referred USAID patients underwent underwent screening for the presence of an interferon signature using a standardized type-I IFN-response-gene...
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