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Homocysteine Metabolites Inhibit Autophagy and Elevate Amyloid Beta by Impairing Phf8/H4K20me1-dependent Epigenetic Regulation of mTOR in Cystathionine β-Synthase-Deficient Mice

2023-03-22

Abstract excerpt

The loss of cystathionine β-synthase (CBS), an important homocysteine (Hcy)-metabolizing enzyme or the loss of PHF8, an important histone demethylase participating in epigenetic regulation, causes severe mental retardation in humans. Similar neuropathies were also observed in Cbs -/- and Phf8 -/- mice. How CBS or PHF8 depletion can cause neuropathy was unknown. To answer this question, we examined a possible int...

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Literature Corpus work: c5a2a1a7-836b-5052-8dac-3851c663d324
DOI: 10.1101/2023.03.22.533769

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