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Article

Desmosomal protein structure and function and the impact of disease-causing mutations.

Journal of structural biology - 1 Sept 2021

Mohammed Fiyaz, Chidgey Martyn

Abstract excerpt

In this graphical review we focus on the structural characteristics of desmosomal proteins, their interactions with each other and with the intermediate filament cytoskeleton. The wealth of structural information that is now available allows predictions to be made about the pathogenic effect of disease-causing mutations. We have selected representative examples of missense mutations that are buried, semi-buried...

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Identifiers

PMID: 34033898
DOI: 10.1016/j.jsb.2021.107749

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