Article

Chromosomal instability mediates immune exclusion and response to cytotoxic chemotherapy in colorectal liver metastases

2021-09-23

Abstract excerpt

The genomic drivers of immune exclusion in colorectal cancer liver metastases (CRCLM) remain poorly understood. Chromosomal instability (CIN), resulting in aneuploidy and genomic rearrangements, is the central pathway of mismatch repair-proficient colorectal cancer pathogenesis; however, it is unknown whether CIN impacts the outcomes of patients with limited spread of CRCLM treated with curative intent cytotoxic c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c58f94de-877a-59bd-a047-54b7ca676c43
DOI: 10.1101/2021.09.22.459429

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Chromosomal instability mediates immune exclusion and response to cytotoxic chemotherapy in colorectal liver metastasesDOI 10.1101/2021.09.22.459429Read

Genomic instability as a driver and suppressor of anti-tumor immunitySemantic proximity Read

The Role of Chromosomal Instability in Cancer and Therapeutic ResponsesSemantic proximity Read

Chromosomal instability: a key driver in glioma pathogenesis and progressionSemantic proximity Read

Genome instability and crosstalk with the immune responseSemantic proximity Read

Genome-wide differential genetic profiling characterizes colorectal cancers with genetic instability and specific routes to HLA class I loss and immune escapeSemantic proximity Read

The chromosomal instability pathway in colon cancer.Semantic proximity Read

Signatures of chromosomal instability in human cancersSemantic proximity Read

Ultrasensitive Detection of Chromosomal Instability in Ascites as a Novel Diagnostic for Peritoneal CarcinomatosisSemantic proximity Read

DNA Damage and Repair Biomarkers of Immunotherapy ResponseSemantic proximity Read

Immune Cytolytic Activity Correlates with Tumor Microenvironmental Aberrations in Colorectal Cancer.Semantic proximity Read

Profiling Numerical and Structural Chromosomal Instability in Different Cancer Types.Semantic proximity Read

Paradoxical relationship between chromosomal instability and survival outcome in cancer.Semantic proximity Read