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Article

Paradoxical relationship between chromosomal instability and survival outcome in cancer.

Cancer research - 15 May 2011

Birkbak Nicolai J, Eklund Aron C, Li Qiyuan, McClelland Sarah E, Endesfelder David, Tan Patrick, Tan Iain B, Richardson Andrea L, Szallasi Zoltan, Swanton Charles

Abstract excerpt

Chromosomal instability (CIN) is associated with poor prognosis in human cancer. However, in certain animal tumor models elevated CIN negatively impacts upon organism fitness, and is poorly tolerated by cancer cells. To better understand this seemingly contradictory relationship between CIN and cancer cell biological fitness and its relationship with clinical outcome, we applied the CIN70 expression signature,...

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Identifiers

PMID: 21270108
DOI: 10.1158/0008-5472.CAN-10-3667
PMCID: PMC3096721

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