Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genome instability and crosstalk with the immune response

4 Nov 2025

Abstract excerpt

Genome instability, tumour-promoting inflammation, and immune escape are three distinct hallmarks of cancer. However, accumulating scientific and clinical evidence over the past decade have uncovered a multifaceted interplay of complex dynamic network of interactions between genome instability, the DNA damage response (DDR), and tumour immunogenicity. Fuelled by the clinical successes of immune checkpoint...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Ferroptosis and cancer prognosis
Share to PARP inhibition in cancer therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 41188872
DOI: 10.1186/s13073-025-01509-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genome instability and crosstalk with the immune responsePMID 41188872Read ↗

Genomic instability as a driver and suppressor of anti-tumor immunitySemantic proximity Read ↗

DNA Damage and Repair Biomarkers of Immunotherapy ResponseSemantic proximity Read ↗

Interplay between the DNA Damage Response and Immunotherapy Response in CancerSemantic proximity Read ↗

The complementarity of DDR, nucleic acids and anti-tumour immunity.Semantic proximity Read ↗

Error‐prone DNA repair pathways as determinants of immunotherapy activity: an emerging scenario for cancer treatmentSemantic proximity Read ↗

The DNA damage induced immune response: Implications for cancer therapySemantic proximity Read ↗

DNA Repair and Signaling in Immune-Related Cancer TherapySemantic proximity Read ↗

Immune escape and resistance to immunotherapy in mismatch repair deficient tumorsSemantic proximity Read ↗

DNA Repair Deficiency Regulates Immunity Response in Cancers: Molecular Mechanism and Approaches for Combining ImmunotherapySemantic proximity Read ↗

Molecular and Genomic Determinants of Response to Immune Checkpoint Inhibition in CancerSemantic proximity Read ↗

Microsatellite Instability in Colorectal Cancers: Carcinogenesis, Neo-Antigens, Immuno-Resistance and Emerging TherapiesSemantic proximity Read ↗

Mechanism of immune activation mediated by genomic instability and its implication in radiotherapy combined with immune checkpoint inhibitorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.