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DNA Damage and Repair Biomarkers of Immunotherapy Response

19 Jun 2017

Abstract excerpt

Abstract DNA-damaging agents are widely used in clinical oncology and exploit deficiencies in tumor DNA repair. Given the expanding role of immune checkpoint blockade as a therapeutic strategy, the interaction of tumor DNA damage with the immune system has recently come into focus, and it is now clear that the tumor DNA repair landscape has an important role in driving response to immune checkpoint blockade....

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PMID: 28630051
DOI: 10.1158/2159-8290.cd-17-0226

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