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The Associations of Selenoprotein Genetic Variants with the Risks of Colorectal Adenoma and Colorectal Cancer: Case-Control Studies in Irish and Czech Populations.

Nutrients - 29 Jun 2022

Mukhtar Maryam, Ashfield Niall, Vodickova Ludmila, Vymetalkova Veronika, Levy Miroslav, Liska Václav, Bruha Jan, Bendova Petra, O'Sullivan Jacintha, Doherty Glen, Sheahan Kieran, Nolan Blathnaid, Vodicka Pavel, Hughes David J

Abstract excerpt

BACKGROUND: Selenium manifests its biological effects through its incorporation into selenoproteins, which play several roles in countering oxidative and inflammatory responses implicated in colorectal carcinogenesis. Selenoprotein genetic variants may contribute to colorectal cancer (CRC) development, as we previously observed for SNP variants in a large European prospective study and a Czech case-control...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35807897
DOI: 10.3390/nu14132718
PMCID: PMC9268344

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