Article

Coupling translation termination to RNA surveillance: roles of release factors in quality control and RNA degradation pathways in mammalian mitochondria

2025-07-22

Abstract excerpt

<title>Abstract</title> <p>Accurate protein synthesis depends on the proper recognition of stop codons by release factors (RFs). The human mitochondrial genome deviates from the standard genetic code by using not only the canonical stop codons UAG and UAA but also two non-canonical stop codons, AGA and AGG. Consequently, human mitochondria employ two release factors—mtRF1a and mtRF1—that recognize canonical and n...

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Literature Corpus work: c51700ba-32f2-55cd-b5f3-6118b2aba1fc
DOI: 10.21203/rs.3.rs-7036318/v1

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