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Article

Autoimmunity to uroplakin II causes cystitis in mice: a novel model of interstitial cystitis.

European urology - 1 Jan 2012

Altuntas Cengiz Z, Daneshgari Firouz, Sakalar Cagri, Goksoy Esen, Gulen M Fatih, Kavran Michael, Qin Jun, Li Xiaoxia, Tuohy Vincent K

Abstract excerpt

BACKGROUND: The pathophysiology of interstitial cystitis (IC) is unknown. Deficits in urothelial cell layers and autoimmune mechanisms may play a role. OBJECTIVE: To examine whether immunization of mice with recombinant mouse uroplakin II (rmUPK2), a bladder-specific protein, would provoke an autoimmune response sufficient to create an IC phenotype. DESIGN, SETTING, AND PARTICIPANTS: RmUPK2 complementary DNA was...

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Identifiers

PMID: 21719190
DOI: 10.1016/j.eururo.2011.06.028
PMCID: PMC3226908

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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