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Disruption of the MICOS complex leads to an aberrant cristae structure and an unexpected, pronounced lifespan extension in <i>Podospora anserina</i>

2022-03-21

Abstract excerpt

Mitochondria are dynamic eukaryotic organelles involved in a variety of essential cellular processes including the generation of adenosine triphosphate (ATP) and reactive oxygen species (ROS) as well as in the control of apoptosis and autophagy. Impairments of mitochondrial functions lead to aging and disease. Previous works with the ascomycete Podospora anserina demonstrated that mitochondrial morphotype as well...

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Literature Corpus work
c503e22c-eea2-538c-bc8d-9550a5508214
DOI
10.1101/2022.03.21.485166
Open publication

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