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Article

Stress-dependent opposing roles for mitophagy in aging of the ascomycete Podospora anserina.

Autophagy - 3 Jun 2017

Knuppertz Laura, Warnsmann Verena, Hamann Andrea, Grimm Carolin, Osiewacz Heinz D

Abstract excerpt

Mitochondrial dysfunction is causatively linked to organismal aging and the development of degenerative diseases. Here we describe stress-dependent opposing roles of mitophagy, the selective autophagic degradation of mitochondria, in aging and life-span control. We report that the ablation of the mitochondrial superoxide dismutase which is involved in reactive oxygen species (ROS) balancing, does not affect life...

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Identifiers

PMID: 28368682
DOI: 10.1080/15548627.2017.1303021
PMCID: PMC5486364

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