Article

Microglia Rank signaling regulates GnRH function and the Hypothalamic-Pituitary-Gonadal axis

2026-02-18

Abstract excerpt

The hypothalamic-pituitary-gonadal axis (HPG) controls pubertal development, sexual maturation, and fertility. We hereby demonstrate a new role of hypothalamic microglia in controlling the HPG axis through Rank signaling, a pathway known for its role in bone and mammary gland biology. Whole-body and microglia Rank depletion leads to hypogonadotropic hypogonadism (HH) resulting from an alteration in gonadotropin-re...

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Literature Corpus work: c4e16a12-41ae-5051-a648-2063d4e00809
DOI: 10.64898/2026.02.18.706528

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