Article

SEMA6A drives GnRH neuron-dependent puberty onset by tuning median eminence vascular permeability

2023-10-26

Abstract excerpt

<h4>ABSTRACT</h4> Innervation of the hypothalamic median eminence by Gonadotropin-Releasing Hormone (GnRH) neurons is vital to ensure puberty onset and successful reproduction. However, the molecular and cellular mechanisms underlying median eminence development and pubertal timing are incompletely understood. Here we show that Semaphorin-6A is strongly expressed by median eminence-resident oligodendrocytes positi...

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Literature Corpus work: 8e4aa2ec-4948-56ca-b16a-4f967c057500
DOI: 10.1101/2023.10.24.23297449

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