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Article

Integrative single-cell, spatial, and bulk transcriptomics reveal an FMR1-FTO axis linked to the immune-excluded phenotype in gastric cancer.

Frontiers in immunology - 1 Jan 2026

Mao Chenxi, Zhang Miao, Zhou Kangjie, Hong Yidong, Han Yiqian, Zhao Luming, Liang Mingtong, Zhang Jingzhou, Hu Nan, Wu Fenglei

Abstract excerpt

Background: Immune exclusion is a major barrier to immune checkpoint inhibitor (ICI) efficacy in gastric cancer, yet the spatial mechanisms by which m6A regulators drive this phenotype remain unclear. Methods: We integrated single-cell RNA-seq, spatial transcriptomics, and functional assays to map the gastric cancer microenvironment and derived an m6A regulator score to quantify the spatial coupling between m6A...

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Source

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Identifiers

PMID: 41878447
DOI: 10.3389/fimmu.2026.1713267
PMCID: PMC13006672

Genes

FTO
FMR1
MIF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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