Comb-structured mRNA vaccine tethered with short double-stranded RNA adjuvants maximizes cellular immunity for cancer treatment

Abstract excerpt

<h4>ABSTRACT</h4> Integrating antigen-encoding mRNA and immunostimulatory adjuvant into a single formulation is a promising approach to potentiating the efficacy of mRNA vaccines. Here, we developed a scheme based on RNA engineering to integrate adjuvancy directly into antigen-encoding mRNA strands without hampering the ability to express antigen proteins. Short double-stranded RNA (dsRNA) was designed to target...

Topics

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• Animal Virus Infections Studies
• CAR-T cell therapy research
• Immunotherapy and Immune Responses
• RNA and protein synthesis mechanisms
• RNA Interference and Gene Delivery
• SARS-CoV-2 and COVID-19 Research
• Viral gastroenteritis research and epidemiology
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

ccb198d5-71ee-53d1-98ee-45a5fe6e67f3

DOI

10.1101/2022.01.18.476829