Article

Functional studies of the human papillomavirus E7 protein

2000-01-01

Abstract excerpt

El is the major Human Papillomavirus transforming protein. Mutations in regions of E7 result in a loss or reduction of transforming activity even through wild type levels of pRB binding are retained, indicating the existence of additional cellular targets. I performed a series of experiments to investigate whether HPV E7, like AdEla, can bind to TBP. E7 from both benign- and malignancy-associated HPVs binds to TBP...

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Literature Corpus work: c4aa4884-e1f5-503b-8780-139bb3ab7953
DOI: 10.21954/ou.ro.0000ff62

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