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Article

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.

Journal of virology - 1 Apr 1992

Phelps W C, Münger K, Yee C L, Barnes J A, Howley P M

Abstract excerpt

The E7 gene of human papillomavirus type 16 encodes a multifunctional nuclear phosphoprotein that is functionally and structurally similar to the adenovirus (Ad) E1A proteins and the T antigens of other papovaviruses. E7 can cooperate with an activated ras oncogene to transform primary rodent cells, trans activate the Ad E2 promoter, and abrogate transforming growth factor beta-mediated repression of c-myc....

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Identifiers

PMID: 1312637
DOI: 10.1128/JVI.66.4.2418-2427.1992
PMCID: PMC289037

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