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Article

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein.

Journal of virology - 1 Apr 1992

Phelps W C, Münger K, Yee C L, Barnes J A, Howley P M

Abstract excerpt

The E7 gene of human papillomavirus type 16 encodes a multifunctional nuclear phosphoprotein that is functionally and structurally similar to the adenovirus (Ad) E1A proteins and the T antigens of other papovaviruses. E7 can cooperate with an activated ras oncogene to transform primary rodent cells, trans activate the Ad E2 promoter, and abrogate transforming growth factor beta-mediated repression of c-myc....

Topics

Amino Acid Sequence
Cell Transformation, Viral
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Oncogene Proteins, Viral
Papillomaviridae
Papillomavirus E7 Proteins
Phosphorylation
Protein Conformation
Sequence Alignment

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Transcriptional Activation

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Identifiers

PMID: 1312637
DOI: 10.1128/JVI.66.4.2418-2427.1992
PMCID: PMC289037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1312637-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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