Article
Repression of p53 transcriptional activity by the HPV E7 proteins.
Virology - 6 Jan 1997
Massimi P, Banks L
Abstract excerpt
The major transforming protein of human papillomaviruses (HPVs) is encoded by the E7 gene. This protein cooperates with activated oncogenes to transform primary rodent cells and with the viral E6 gene to immortalize primary human keratinocytes. Numerous cellular targets of HPV E7 have now been identified including pRb, p107, cyclin A, TATA box binding protein (TBP), and members of the AP-1 transcription factor...
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