Repression of p53 transcriptional activity by the HPV E7 proteins.

doi:10.1006/viro.1996.8315

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Article

Repression of p53 transcriptional activity by the HPV E7 proteins.

Virology - 6 Jan 1997

Massimi P, Banks L

Abstract excerpt

The major transforming protein of human papillomaviruses (HPVs) is encoded by the E7 gene. This protein cooperates with activated oncogenes to transform primary rodent cells and with the viral E6 gene to immortalize primary human keratinocytes. Numerous cellular targets of HPV E7 have now been id...

Topics

Binding Sites
Cell Line
Cyclin-Dependent Kinase Inhibitor p21
Cyclins
Gene Expression Regulation, Viral
Genes, p53
Humans
Mutation
Oncogene Proteins, Viral
Papillomaviridae
Papillomavirus E7 Proteins
Phosphorylation
Recombinant Fusion Proteins
Transcription, Genetic

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