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Epigenetic Changes in Islets of Langerhans Preceding the Onset of Diabetes

17 Aug 2020

Abstract excerpt

The identification of individuals with a high risk of developing type 2 diabetes (T2D) is fundamental for prevention. Here, we used a translational approach and prediction criteria to identify changes in DNA methylation visible before the development of T2D. Islets of Langerhans were isolated from genetically identical 10-week-old female New Zealand Obese mice, which differ in their degree of hyperglycemia and in...

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PMID: 32816961
DOI: 10.2337/db20-0204

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