Article

SMARCB1 loss interacts with neuronal differentiation state to block maturation and impact cell stability

2020-05-05

Abstract excerpt

Atypical teratoid rhabdoid tumors (ATRT) are challenging pediatric brain cancers which are predominantly associated with inactivation of the gene SMARCB1, a conserved subunit of the chromatin remodeling BAF complex, which has known contributions to developmental processes. To identify potential interactions between SMARCB1 loss and the process of neural development, we introduced an inducible SMARCB1 loss of funct...

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Literature Corpus work: c49975c5-94b0-52b1-8fb3-68410dcc8c76
DOI: 10.1101/2020.05.04.074443

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