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Atypical teratoid/rhabdoid tumors—current concepts, advances in biology, and potential future therapies

10 Jan 2016

Abstract excerpt

Atypical teratoid/rhabdoid tumor (AT/RT) is the most common malignant CNS tumor of children below 6 months of age. The majority of AT/RTs demonstrate genomic alterations in SMARCB1 (INI1, SNF5, BAF47) or, to a lesser extent, SMARCA4 (BRG1) of the SWItch/sucrose nonfermentable chromatin remodeling complex. Recent transcription and methylation profiling studies suggest the existence of molecular subgroups. Thus, at...

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PMID: 26755072
DOI: 10.1093/neuonc/nov264

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