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Article

Comprehensive deep mutational scanning reveals the pH induced stability and binding differences between SARS-CoV-2 spike RBD and human ACE2.

Journal of biomolecular structure & dynamics - 1 Jan 2023

Haque Shafiul, Mathkor Darin Mansor, Alkhanani Mustfa Faisal, Bantun Farkad, Momenah Aiman M, Faidah Hani, Jalal Naif A, Kumar Vijay

Abstract excerpt

The SARS-CoV-2 spike (S) glycoprotein with its mobile receptor-binding domain (RBD), binds to the human ACE2 receptor and thus facilitates virus entry through low-pH-endosomal pathways. The high degree of SARS-CoV-2 mutability has raised concern among scientists and medical professionals because it created doubt about the effectiveness of drugs and vaccinations designed specifically for COVID-19. In this study,...

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Identifiers

PMID: 36995177
DOI: 10.1080/07391102.2023.2194007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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