Fast and Deep Phosphoproteome Analysis with the Orbitrap Astral Mass Spectrometer

Abstract excerpt

<h4>ABSTRACT</h4> Owing to its roles in cellular signal transduction, protein phosphorylation plays critical roles in myriad cell processes. That said, detecting and quantifying protein phosphorylation has remained a challenge. We describe the use of a novel mass spectrometer (Orbitrap Astral) coupled with data-independent acquisition (DIA) to achieve rapid and deep analysis of human and mouse phosphoproteomes. W...

Topics

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• Databases, Protein
• Disease
• Internet
• Mutation, Missense
• Position-Specific Scoring Matrices
• Protein Kinases
• Protein Processing, Post-Translational
• Sequence Analysis, Protein

Identifiers and source

Literature Corpus work

3c8e84ad-66e7-5ee4-a1ec-788d69e403f4

DOI

10.1101/2023.11.21.568149