Article
circAβ RNA drives the formation and deposition of β-amyloid plaques in the sporadic Alzheimer’s disease
2022-08-07
Abstract excerpt
β-amyloid peptides (Aβ) play key causal role in Alzheimer’s disease (AD). However, the mechanisms of Aβ biogenesis in sporadic AD are still largely unknown. Moreover, current AD mouse models which overexpress mutated human APP and presenilin proteins can only mimic limited characteristics of familial AD. We recently discovered an alternative Aβ production pathway from Aβ175, an Aβ peptide containing polypeptide tr...
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Identifiers and source
- Literature Corpus work
- 78ca587c-c2c1-5b07-a414-47db2cfc9716
- DOI
- 10.1101/2022.08.07.503077