Article

Distinct estrogenic transcription programs of estetrol and estradiol across mammary, uterine, and vaginal cell types of pseudomenopaused mice

2026-06-22

Abstract excerpt

<title>Abstract</title> <p>Menopause results from a marked decline in estrogen production and leads to symptoms that impair quality of life. Menopausal hormone therapy is effective in alleviating these symptoms; however, it is associated with an increased risk of estrogen receptor-positive (ER+) breast cancer. Estetrol (E4), a natural fetal estrogen produced by the liver, has emerged as a promising alternative, r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4821301-5416-58aa-ac5c-08883d900a7e
DOI: 10.21203/rs.3.rs-9812305/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct estrogenic transcription programs of estetrol and estradiol across mammary, uterine, and vaginal cell types of pseudomenopaused miceDOI 10.21203/rs.3.rs-9812305/v1Read

Estetrol and Mammary Gland: Friends or Foes?Semantic proximity Read

Self-renewal and phenotypic conversion are the main physiological responses of macrophages to the endogenous estrogen surge.Semantic proximity Read

ERα-independent NRF2-mediated immunoregulatory activity of tamoxifenSemantic proximity Read

Estrogen-Dependent Gene Expression in the Mouse OvarySemantic proximity Read

Systematic characterization of the ovarian landscape across mouse menopause modelsSemantic proximity Read

Unconventional Estrogen Signaling in Health and DiseaseSemantic proximity Read

ERα-independent NRF2-mediated immunoregulatory activity of tamoxifen.Semantic proximity Read

Endometrial Hyperplasia Risk Is Increased by High-Fat Diet Via Estrogen-Driven Stromal Fibroblast Reprogramming Toward a Pro-Fibrotic StateSemantic proximity Read

Estrogen Receptors: How Do They Signal and What Are Their TargetsSemantic proximity Read

Regulation of Aromatase Expression in Estrogen-Responsive Breast and Uterine Disease: From Bench to TreatmentSemantic proximity Read

Estrogen receptors regulate innate immune cells and signaling pathwaysSemantic proximity Read

Single-Cell Transcription Mapping of Murine and Human Mammary Organoids Responses to Female HormonesSemantic proximity Read