Article

Impairment of proteasome-associated deubiquitinating enzyme Uchl5/UBH-4 affects autophagy

2024-04-06

Abstract excerpt

The autophagy-lysosomal pathway (ALP) and the ubiquitin-proteasome system (UPS) are the two major intracellular proteolytic systems that mediate protein turnover in eukaryotes. Although a crosstalk exists between these two systems, it is still unclear how UPS and ALP interact in vivo . Here, we have investigated how impaired function of the proteasome-associated deubiquitinating enzyme (DUB) Uchl5/UBH-4, a regula...

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Literature Corpus work: c4548d17-1f3a-5f52-8b6a-68c60a8aa7a8
DOI: 10.1101/2024.04.04.588054

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