Article

Fluorescent reporter of Caenorhabditis elegans Parkin: Regulators of its abundance and role in autophagy-lysosomal dynamics

2023-09-15

Abstract excerpt

<h4>Background: </h4> Parkin, which when mutated leads to early-onset Parkinson’s disease, acts as an E3 ubiquitin ligase. How Parkin is regulated for selective protein and organelle targeting is not well understood. Here, we used protein interactor and genetic screens in Caenorhabditis elegans ( C. elegans) to identify new regulators of Parkin abundance and showed their impact on autophagy-lysosomal dynamics an...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 483bc9d9-12f0-599e-8643-7645c0add5b8
DOI: 10.12688/openreseurope.14235.2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Fluorescent reporter of Caenorhabditis elegans Parkin: Regulators of its abundance and role in autophagy-lysosomal dynamicsDOI 10.12688/openreseurope.14235.2Read

A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stressSemantic proximity Read

Modeling Parkinson's Disease in C. elegans.Semantic proximity Read

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagySemantic proximity Read

Rab11 regulates mitophagy signaling pathway of Parkin and Pink1 in the Drosophila model of Parkinson's diseaseSemantic proximity Read

C. elegans Model Identifies Genetic Modifiers of α-Synuclein Inclusion Formation During AgingSemantic proximity Read

Analysis of α-syn and parkin interaction in mediating neuronal death in Drosophila model of Parkinson's diseaseSemantic proximity Read

Modelling the functional genomics of Parkinson's disease in Caenorhabditis elegans: LRRK2 and beyond.Semantic proximity Read

Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson’s DiseaseSemantic proximity Read

Functional Screening of Parkinson’s Disease Susceptibility Genes to Identify Novel Modulators of α-Synuclein Neurotoxicity in Caenorhabditis elegansSemantic proximity Read

Vulnerable Parkin Loss-of-Function Drosophila Dopaminergic Neurons Have Advanced Mitochondrial Aging, Mitochondrial Network Loss and Transiently Reduced Autophagosome RecruitmentSemantic proximity Read

LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's diseaseSemantic proximity Read

Absence of pretaporter restrains features of the parkin phenotype in Drosophila.Semantic proximity Read