Article

Subset-specific mitochondrial and DNA damage shapes T cell responses to fever and inflammation

2022-11-15

Abstract excerpt

Heat is a cardinal feature of inflammation. Despite temperature variability and dependence of enzymes and complexes, how heat and fever affect immune cells remains uncertain. We found that heat broadly increased inflammatory activity of CD4 + T cell subsets and decreased Treg suppressive function. Th1 cells, however, also selectively developed mitochondrial dysfunction with high levels of ROS production and DNA d...

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Literature Corpus work: c44d822e-406e-56f7-a599-b664b1546b4b
DOI: 10.1101/2022.11.14.516478

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