Article
Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells.
Cancer immunology research - 1 Oct 2016
Homet Moreno Blanca, Zaretsky Jesse M, Garcia-Diaz Angel, Tsoi Jennifer, Parisi Giulia, Robert Lidia, Meeth Katrina, Ndoye Abibatou, Bosenberg Marcus, Weeraratna Ashani T, Graeber Thomas G, Comin-Anduix Begoña, Hu-Lieskovan Siwen, Ribas Antoni
Abstract excerpt
The programmed cell death protein 1 (PD-1) limits effector T-cell functions in peripheral tissues, and its inhibition leads to clinical benefit in different cancers. To better understand how PD-1 blockade therapy modulates the tumor-host interactions, we evaluated three syngeneic murine tumor models, the BRAFV600E-driven YUMM1.1 and YUMM2.1 melanomas, and the carcinogen-induced murine colon adenocarcinoma MC38....
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