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From toxicogenomics data to cumulative assessment groups: a framework for chemical grouping.

Archives of toxicology - 1 Jan 2026

Canzler Sebastian, Lehmann Julienne, Schor Jana, Busch Wibke, Iacono Giovanni, Hackermüller Jörg

Abstract excerpt

The grouping of chemicals based on common properties or molecular mechanisms of action is pivotal for advancing regulatory toxicology, reducing data gaps, and enabling cumulative risk assessments. This study introduces a novel framework using chemical-gene-phenotype-disease (CGPD) tetramers derived from the Comparative Toxicogenomics Database (CTD). Our approach integrates publicly available toxicogenomics data...

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Identifiers

PMID: 41003772
DOI: 10.1007/s00204-025-04133-w
PMCID: PMC12858531

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