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The HDAC2-selective inhibitor KTT-1 attenuates autoimmune arthritis by inhibiting osteoclast differentiation in mice

2025-10-21

Abstract excerpt

Histone deacetylases (HDACs) are crucial epigenetic regulators of gene expression through the reversible acetylation of lysine residues, and their inhibition is known to exert anti-arthritic effects. Given the critical role of osteoclasts in bone destruction in rheumatoid arthritis (RA) pathogenesis, targeting HDAC2—whose expression is upregulated during osteoclast differentiation—represents a promising therapeuti...

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Literature Corpus work
c42b0eef-ff8b-5462-8b86-04db80bde512
DOI
10.1101/2025.10.20.683312
Open publication

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The HDAC2-selective inhibitor KTT-1 attenuates autoimmune arthritis by inhibiting osteoclast differentiation in miceDOI 10.1101/2025.10.20.683312
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