Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Role of HDACs and HDACi in Cartilage and Osteoarthritis

30 Sept 2020

Abstract excerpt

Epigenetics plays an important role in the pathogenesis and treatment of osteoarthritis (OA). In recent decades, HDAC family members have been associated with OA. This paper aims to describe the different role of HDACs in the pathogenesis of OA through interaction with microRNAs and the regulation of relevant signaling pathways. We found that HDACs are involved in cartilage and chondrocyte development but also...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Histone Deacetylase Inhibitors Research
Share to Inflammatory mediators and NSAID effects
Share to Osteoarthritis Treatment and Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33102472
DOI: 10.3389/fcell.2020.560117

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Role of HDACs and HDACi in Cartilage and OsteoarthritisPMID 33102472Read ↗

Epigenetics in osteoarthritis: Potential of HDAC inhibitors as therapeuticsSemantic proximity Read ↗

Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs.Semantic proximity Read ↗

Epigenetic mechanisms and non-coding RNAs in osteoarthritis.Semantic proximity Read ↗

Epigenetic regulation of gene expression in osteoarthritisSemantic proximity Read ↗

Epigenetics as a Therapeutic Target in OsteoarthritisSemantic proximity Read ↗

Histone Modifications and Chondrocyte Fate: Regulation and Therapeutic ImplicationsSemantic proximity Read ↗

Decreased histone deacetylase 4 is associated with human osteoarthritis cartilage degeneration by releasing histone deacetylase 4 inhibition of runt-related transcription factor-2 and increasing osteoarthritis-related genes: a novel mechanism of human osteoarthritis cartilage degenerationSemantic proximity Read ↗

Epi-revolution in rheumatology: the potential of histone deacetylase inhibitors for targeted rheumatoid arthritis interventionSemantic proximity Read ↗

Epigenetics in osteoarthritis: Novel spotlightSemantic proximity Read ↗

Interplay of Inflammatory Mediators with Epigenetics and Cartilage Modifications in OsteoarthritisSemantic proximity Read ↗

Epigenetic Regulation of Chondrocytes and Subchondral Bone in OsteoarthritisSemantic proximity Read ↗

Epigenetic and microRNA regulation during osteoarthritis developmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.