Article
Loss of Function ABCG2 c.421C>A (rs2231142) Polymorphism Increases Steady-State Exposure to Mycophenolic Acid in Stable Renal Transplant Recipients: An Exploratory Matched Cohort Study.
Advances in therapy - 1 Feb 2023
Borić-Bilušić A Ana, Božina Nada, Lalić Zdenka, Lovrić Mila, Nađ-Škegro Sandra, Penezić Luka, Barišić Karmela, Trkulja Vladimir
Abstract excerpt
INTRODUCTION: Polymorphism ABCG2 c.421C>A (rs2231142) results in reduced activity of the important drug efflux transporter breast cancer-resistance protein (BCRP/ABCG2). One study has suggested that it may affect enterohepatic recirculation of mycophenolic acid (MPA). We evaluated the effect of rs2231142 on steady-state exposure to MPA in renal transplant recipients. METHODS: Consecutive, stable adult...
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