Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell multi-omics analysis reveals candidate therapeutic drugs and key transcription factor specifically for the mesenchymal subtype of glioblastoma

20 Dec 2024

Abstract excerpt

The inherent heterogeneity of tumor cells impedes the development of targeted therapies for specific glioblastoma (GBM) subtypes. This study aims to investigate the mesenchymal subtype of GBM to uncover detailed characteristics, potential therapeutic strategies, and improve precision treatment for GBM patients. We integrated single-cell RNA sequencing (scRNA-seq), single-nucleus assay for transposase-accessible...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to Immune cells in cancer
Share to Single-cell and spatial transcriptomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39707474
DOI: 10.1186/s13578-024-01332-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell multi-omics analysis reveals candidate therapeutic drugs and key transcription factor specifically for the mesenchymal subtype of glioblastomaPMID 39707474Read ↗

Spatial multi-omics defines a shared glioblastoma infiltrative signature at the resection marginSemantic proximity Read ↗

Multi-omics and pharmacological characterization of patient-derived glioma cell linesSemantic proximity Read ↗

Multi-omics and Pharmacological Characterization of Patient-derived Glioma Cell LinesSemantic proximity Read ↗

Single-cell multi-omics sequencing uncovers region-specific plasticity of glioblastoma for complementary therapeutic targetingSemantic proximity Read ↗

A single-cell atlas of glioblastoma evolution under therapy reveals cell-intrinsic and cell-extrinsic therapeutic targets.Semantic proximity Read ↗

Multiomic profiling of hypoxic glioblastoma stem cells reveals expansion of subpopulations with distinct epigenetic and CNV profilesSemantic proximity Read ↗

Current Applications of Single-Cell RNA Sequencing in Glioblastoma: A Scoping ReviewSemantic proximity Read ↗

Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.Semantic proximity Read ↗

Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysisSemantic proximity Read ↗

Single-cell and spatial atlas of glioblastoma heterogeneity: characterizing the PCLAF+ subtype and YEATS4’s oncogenic roleSemantic proximity Read ↗

Multi‐omic integration of DNA methylation and gene expression data reveals molecular vulnerabilities in glioblastomaSemantic proximity Read ↗

Genomic and Transcriptomic Characterization of the New Human Glioblastoma Cell Line AHOL1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.