Article

Long-read sequencing of diagnosis and post-therapy medulloblastoma reveals complex rearrangement patterns and epigenetic signatures

2022-02-20

Abstract excerpt

<h4>Summary</h4> Cancer genomes harbor a broad spectrum of structural variants (SV) driving tumorigenesis, a relevant subset of which are likely to escape discovery in short reads. We employed Oxford Nanopore Technologies (ONT) sequencing in a paired diagnostic and post-therapy medulloblastoma to unravel the haplotype-resolved somatic genetic and epigenetic landscape. We assemble complex rearrangements and such a...

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Literature Corpus work: c4138a9e-dbba-5359-8f08-8e163d4597e3
DOI: 10.1101/2022.02.20.480758

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