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The repertoire of resistance mutations selected by a <i>Pseudomonas aeruginosa</i> type IV pilus-targeting lytic bacteriophage

2025-11-17

Abstract excerpt

<h4>ABSTRACT</h4> P. aeruginosa type IV pili (T4P) are complex surface-exposed nanomachines used for twitching motility and biofilm formation. Exposure to bacteriophages that use T4P as their primary receptor can select for resistance mutations that reduce or abolish pilus expression. Since T4P are important virulence factors, such loss can affect pathogenicity and fitness, desirable outcomes for phage therapy. H...

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Literature Corpus work
c413573f-beb9-5a76-9cd3-49378716bf4b
DOI
10.1101/2025.11.17.688846
Open publication

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The repertoire of resistance mutations selected by a <i>Pseudomonas aeruginosa</i> type IV pilus-targeting lytic bacteriophageDOI 10.1101/2025.11.17.688846
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