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Isolation of a Novel Lytic Pseudomonas aeruginosa Phage Henu5 and Fitness Costs of Phage-Driven Resistance.

Microbial biotechnology - 1 Jun 2026

Gomaa Salwa E, Shen Jiawen, Li Jingjing, Liu Yangyang, Ma Chaonan, Li Qiming, Qi Guanbin, Teng Tieshan

Abstract excerpt

Phage therapy is increasingly recognised as a potential approach against antibiotic-resistant infections. Analogous to the rise of antibiotic resistance, bacteria can also evolve phage resistance, a process that frequently entails fitness costs. In this study, a new lytic Pseudomonas aeruginosa phage (Henu5) was isolated and characterised. Henu5 was classified within the Caudoviricetes class and displayed good...

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PMID: 42206754
DOI: 10.1111/1751-7915.70389
PMCID: PMC13238721

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