Article

Production of an anti-angiogenic factor sFLT1 is suppressed via promoter hypermethylation of FLT1 gene in choriocarcinoma cells

2020-02-04

Abstract excerpt

<title>Abstract</title> <p>Background: Soluble Fms-like tyrosine kinase-1 (sFLT1) as an anti-angiogenic factor is abundantly expressed in placental trophoblasts. Choriocarcinoma, a malignant tumor derived from trophoblasts, is known to be highly angiogenic and metastatic. However, the molecular mechanism underlying angiogenesis in choriocarcinoma pathogenesis remains unclear. We aimed to investigate the mRNA expr...

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Literature Corpus work: c4073b0d-a1fb-55c0-acd2-29ad93d94063
DOI: 10.21203/rs.2.18159/v3

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