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CRISPR/Cas9-mediated mutations in both a cAMP response element and an ETS-binding site suppress FLT1 gene expression

2022-09-28

Abstract excerpt

The Fms-like tyrosine kinase-1 (FLT1) gene is expressed in various types of cells, including vascular endothelial cells and placental trophoblasts, and regulates angiogenesis, inflammation, and pregnancy. However, the basal transcriptional machinery of FLT1 is still not well understood. In this study, we first examined FLT1 promoter activity in three different types of cells, that is, trophoblast-derived cells, va...

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Identifiers and source

Literature Corpus work
2f16bd23-0a9d-505d-b8cf-20f013979979
DOI
10.21203/rs.3.rs-2047890/v1
Open publication

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CRISPR/Cas9-mediated mutations in both a cAMP response element and an ETS-binding site suppress FLT1 gene expressionDOI 10.21203/rs.3.rs-2047890/v1
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