Article
Altered methylation and expression patterns of genes regulating placental angiogenesis in preterm pregnancy.
Reproductive sciences (Thousand Oaks, Calif.) - 1 Dec 2014
Sundrani Deepali P, Reddy Umakar S, Chavan-Gautam Preeti M, Mehendale Savita S, Chandak Giriraj R, Joshi Sadhana R
Abstract excerpt
INTRODUCTION: Altered angiogenesis has been implicated in the pathogenesis of various pregnancy complications, particularly preeclampsia. At present, there is a lack of data on the possible role of angiogenesis and its molecular mechanism in preterm pregnancy. We have previously reported reduced placental global DNA methylation levels in preterm pregnancy. Now, we have extended the study to examine plasma levels...
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