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A Novel Human-Specific Soluble Vascular Endothelial Growth Factor Receptor 1

31 May 2008

Abstract excerpt

A human-specific splicing variant of vascular endothelial growth factor (VEGF) receptor 1 (Flt1) was discovered, producing a soluble receptor (designated sFlt1-14) that is qualitatively different from the previously described soluble receptor (sFlt1) and functioning as a potent VEGF inhibitor. sFlt1-14 is generated in a cell type-specific fashion, primarily in nonendothelial cells. Notably, in vascular smooth...

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PMID: 18515749
DOI: 10.1161/circresaha.108.171504

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