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Article

A highly unusual thioester bond in a pilus adhesin is required for efficient host cell interaction.

The Journal of biological chemistry - 29 Oct 2010

Pointon Jonathan A, Smith Wendy D, Saalbach Gerhard, Crow Allister, Kehoe Michael A, Banfield Mark J

Abstract excerpt

Many bacterial pathogens present adhesins at the tips of long macromolecular filaments known as pili that are often important virulence determinants. Very little is known about how pili presented by Gram-positive pathogens mediate host cell binding. The crystal structure of a pilus adhesin from the important human pathogen Streptococcus pyogenes reveals an internal thioester bond formed between the side chains of...

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Identifiers

PMID: 20729215
DOI: 10.1074/jbc.M110.149385
PMCID: PMC2962485

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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