Article

Tumor Edge-to-Core Transition Promotes Malignancy in Primary-to-Recurrent Glioblastoma Progression in a PLAGL1/CD109-mediated mechanism

2020-09-15

Abstract excerpt

<h4>Background</h4> Glioblastoma remains highly lethal due to its inevitable recurrence. This recurrence is found locally in most cases, indicating that post-surgical tumor-initiating cells (TICs) accumulate at tumor edge. These edge TICs then generate recurrent tumors harboring new core lesions. Here, we investigated the clinical significance of the edge-to-core transition (ECT) signature causing glioblastoma re...

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Literature Corpus work: c40529d3-be73-5562-a7c5-7e9dd76781de
DOI: 10.1101/2020.09.14.293753

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