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Revealing the glioma cancer stem cell interactome, one niche at a time

27 Dec 2017

Abstract excerpt

Glioblastoma (GBM) cancer stem cells (CSCs) are insidious. They extensively infiltrate brain tissue, resist radiotherapy and chemotherapy, and are thought to represent the ultimate drivers of disease progression. New research has identified CD109, a GPI-anchored protein, on a population of perivascular CSCs. Investigation of primary human tumour tissue suggests a role for CD109-expressing CSCs in the progression...

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PMID: 29282720
DOI: 10.1002/path.5024

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